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The ADVENT-HF Trial

This educational activity is designed to review, in detail, the results of the ADVENT-HF randomized clinical trial.  The effects of a particular type of adaptive servo-ventilation, triggered by changes in peak-flow (ASVPF), on obstructive and central sleep apnea (OSA and CSA, respectively) in patients with heart failure and reduced ejection fraction (HFrEF) will be presented.  The focus will be on the effects of ASVPF reduced on cardiovascular morbidity as well as on sleep structure and health-related quality of life.  The implications of these findings for clinical management of both OSA and CSA in patients with HFrEF will be reviewed.

Target Audience
This activity is intended for medical professionals who have a clinical interest in the management of respiratory patients as seen by the following medical specialists: Pulmonologists, Pneumologists, Respirologists, Respiratory Physiotherapists, Respiratory Therapists (Hospital, Home), Thoracic Surgeons, Home Healthcare Providers, Critical Care Medicine Specialists, Internal Medicine Specialists, Primary Care Physicians (General and Family Practitioners), Advanced Practice Nurses, Nurse Practitioners, Physicians Assistants, Managed Care Medical Directors, and other Practitioners and Payers.

Learning Objectives
After completing this activity, the participant should be better able to:

  1. Examine the necessary elements in lab polysomnogram, and clinical assessment of patients with heart failure and sleep apnea.
  2. Describe the management of sleep apnea in heart failure according to phenotype of sleep apnea and heart failure.
  3. Describe how the results of the ADVENT-HF trial may change the management of heart failure patients with reduced ejection fraction and sleep apnea.
  4. Analyze the impact of the ADVENT-HF study findings on clinical practice by validating the inference that the high prevalence of obstructive sleep apnea (OSA) and central sleep apnea (CSA) in patients with heart failure with reduced ejection fraction (HFrEF) supports a lower threshold for performing diagnostic sleep studies.
  5. Identify which monitoring devices should be avoided as they do not reliably distinguish OSA from CSA.
  6. Explain the discrepancies between randomized trial results and epidemiological data regarding the treatment of OSA and CSA with Adaptive Servo-Ventilation with Positive Pressure Flow in patients with HFrEF.
  7. Identify best practices for treating patients with heart failure with HFrEF and coexisting OSA and CSA based on the ADVENT-HF study findings.
T. Douglas Bradley, MD
Professor of Medicine        
University Health Network Toronto General Hospital
Department of Medicine, Division of Respirology
Toronto, ON, Canada

 

 

Prof. Dr. med. Michael Arzt
Professor of Internal Medicine, Sleep and Ventilation
Centre of Sleep Medicine
Department of Internal Medicine II
University Hospital Regensburg
Regensburg, Germany

 

 

 

 

 

 

 

 

 


Accreditation Statement
The The ADVENT-HF Trial, made available on https://www.medtalks.com/en/advent-hf-trial and organized by Dane Garvin, is accredited by the European Accreditation Council  for Continuing Medical Education (EACCME®) to provide the following CME activity for medical specialists.

Only those e-learning materials that are displayed on the UEMS-EACCME® website have formally been accredited.

Through an agreement between the Union Européenne des Médecins Spécialistes and the American Medical Association, physicians may convert EACCME® credits to an equivalent number of AMA PRA Category 1 Credits TM . Information on the process to convert EACCME® credit to AMA credit can be found at https://edhub.ama-assn.org/pages/applications.

Information regarding the conversion of EACCME® credits
Credit will be converted based on one (1) hour of participation equalling one credit for all activities. Physicians wishing to convert EACCME® credits to AMA PRA Category 1 Credit™ will be required to access the AMA website at https://edhub.ama-assn.org/pages/applications to obtain the necessary paperwork and instructions. Physicians and other health care professionals will be required to pay a processing fee to the AMA.

For other countries, please contact the relevant national/regional accreditation authority.

Educational Grant
This educational activity is independently produced and is financially supported with an unrestricted educational grant by Philips Respironics. 

References 
The ADVENT-HF Trial References

 

Last edited: 03-02-2025
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