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Adaptive Servo Ventilation in Central Sleep Apnoea

Sleep related breathing disturbances can be differentiated in various phenotypes, especially obstructive sleep apnoea, central sleep apnoea and hypoventilation disorders. Central breathing disturbances represent about 10% of the population of sleep apnoea patients. Several underlying diseases predispose to central sleep apnoea, with heart failure with reduced and preserved ejection fraction being the most prevalent comorbidities. Several studies have shown the impact of central sleep apnoea on mortality of heart failure patients. CPAP and oxygen may reduce central breathing disturbances by about 50% and data on long-term outcome are missing. Since its introduction into clinical practice, adaptive servo ventilation has been studied in several cohorts and randomized controlled trials. It normalizes central breathing disturbances, improves oxygen saturation and left ventricular ejection fraction. However, data on long-term outcome are controversial. Therefore, this program will discuss different algorithms of adaptive servo ventilation, the results of cohort studies and randomized controlled trials and discuss current options and future perspectives.

Target Audience
This activity is intended for medical professionals who have a clinical interest in the management of respiratory patients as seen by the following medical specialists: Pulmonologists, Pneumologists, Respirologists, Respiratory Physiotherapists, Respiratory Therapists (Hospital, Home), Thoracic Surgeons, Home Healthcare Providers, Critical Care Medicine Specialists, Internal Medicine Specialists, Primary Care Physicians (General and Family Practitioners), Advanced Practice Nurses, Nurse Practitioners, Physicians Assistants, Managed Care Medical Directors, and other Practitioners and Payers.

Learning Objectives
After completing this activity, the participant should be better able to:

  1. Describe the heterogeneity of phenotypes of central sleep apnoea.
  2. Discuss the pathophysiology of central sleep apnoea in heart failure.
  3. Explain the algorithm of adaptive servoventilation and its differences.
  4. Summarize the impact of central sleep apnoea on outcome of heart failure patients.
  5. Identify differences in outcomes of large randomized controlled trials and cohort studies.

Prof. Dr. med. Winfried J. Randerath
Professor of Medicine
Clinic of Pneumology and Allergology Center for Sleep Medicine and Respiratory Care
Bethanien Hospital
Solingen, Germany

Accreditation Statement
This activity is provided by Dane Garvin Ltd.

Physician Accreditation Statement - EACCME
Dane Garvin is accredited by the European Accreditation Council for Continuing Medical Education (EACCME) to provide the following CME activity.


Physician Credit Designation - EACCME
DaneGarvin designates this enduring material for a maximum of 1.0 UEMS Credits™. Each medical specialist should claim only those hours of credit that he/she actually spent in the educational activity. The EACCME is an institution of the European Union of Medical Specialists (UEMS). Only those e-learning materials that are displayed on the UEMS-EACCME website have formally been accredited. Through an agreement between the European Union of Medical Specialists (UEMS) and the American Medical Association (AMA), physicians may convert EACCME credits to an equivalent number of AMA PRA Category 1 Credits™. Information on the process to convert EACCME credit to AMA credit can be found at

This activity was prepared by Prof. Dr. med. Winfried Randerath and recorded on April 30, 2023, & received US CME approval on October 17th, 2023.

Educational Grant
This educational activity is independently produced and is financially supported with an unrestricted educational grant by Philips. 

Adaptive Servoventilation in Central Sleep Apnoea Current Knowledge And Future Perspectives

Last edited: 29-01-2024
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