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The evidence supporting Ketogenic Therapy for the treatment of serious mental illness

The purpose of this CME activity is to educate practicing physicians and other healthcare professionals about the most recent clinical trials and case series in the field of metabolic psychiatry. This emerging evidence suggests that nutritional ketosis may be a powerful tool as an adjunct to standard medical management of severe mental illness (e.g. bipolar, schizophrenia, depression). By demonstrating that the body of evidence in this field is increasing, we hope to persuade clinicians to consider this type of dietary therapy as an option in the care of their patients.

Target Audience
The main target audiences are primary care and psychiatry physicians, nurse practitioners, and physician assistants. Also, of important consideration are licensed mental health therapists and dieticians.

Learning Objectives
After completing this activity, the participant should be better able to:

  1. Explain the purported mechanisms for a connection between metabolic and mental health.
  2. Describe why metformin can also improve the symptoms of bipolar depression by improving insulin resistance.
  3. Describe the findings of a paper showing that inpatient initiation of a ketogenic diet improved psychiatric symptoms and medication usage for patients with bipolar disorder, major depression, and schizophrenia.
  4. Describe the findings of a study showing that outpatient use of ketogenic diets improved metabolic health and psychiatric symptoms in patients with bipolar disorder and schizophrenia.
  5. Incorporate acquired knowledge on the latest findings on ketogenic therapy for serious mental illness into current practice to better address the needs of their patients, and to optimize patient outcomes.

Matthew Bernstein, MD
Chief Medical Officer, Ellenhorn LLC
Chief Executive Officer &
Chief Medical Officer, Accord Mental Health LLC
Lecturer in Psychiatry, Harvard Medical School

Bret Scher, MD
Cardiologist
Medical Director Baszucki Group & Metabolic Mind
 

 

 

 

 

 

 

 

 

 

 

European Accreditation Council for Continuing Medical Education (EACCME)

EACCME Accreditation Statement
EACCME accreditation is pending.

EACCME Term Offering
Pending.

American Academy of Family Physicians (AAFP) Accreditation

AAFP Accreditation Statement
The AAFP has reviewed The Evidence Supporting Ketogenic Therapy for the Treatment of Serious Mental Illness and deemed it acceptable for up to 1.00 Enduring Materials, Self-Study AAFP Prescribed credit(s). Term of Approval is from 03/18/2025 to 03/18/2026. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Educational Grant
This activity is supported by an educational grant from Metabolic Mind which is a non-profit organization.

References
The Evidence Supporting Ketogenic Therapy for the Treatment of Serious Mental Illness

Last edited: 06-05-2025
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